Methylsulfonylmethane (MSM) has gained attention in recent years as a natural supplement that may help alleviate symptoms of osteoarthritis (OA) and inflammation. While more research is needed, preliminary studies suggest that MSM may provide benefits to those suffering from these conditions. In this article, we will explore what MSM is, how it works, and what the research says about its potential uses.

What is Methylsulfonylmethane (MSM)?

MSM is an organic compound that occurs naturally in some plants, animals, and humans. It is also available as a dietary supplement, often marketed as a joint health supplement. MSM is a source of sulfur, an essential mineral that plays a role in various bodily functions, including building strong connective tissues, maintaining healthy skin, and reducing inflammation.

How Does MSM Work?

One of the ways MSM may benefit those with OA and inflammation is through its anti-inflammatory properties. Inflammation is a natural response of the body's immune system to injury or infection. However, when inflammation becomes chronic, it can lead to tissue damage and pain. MSM has been shown to reduce inflammation by inhibiting the production of certain pro-inflammatory molecules, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) (1).

MSM may also support joint health by promoting the formation of collagen, a structural protein that makes up cartilage, bone, and other connective tissues. As we age, the body's ability to produce collagen decreases, which can lead to joint pain and stiffness. MSM has been shown to stimulate the production of collagen and other proteins that make up connective tissues (2).

What Does the Research Say?

Several studies have investigated the potential benefits of MSM for OA and inflammation. A 2016 review of randomized controlled trials (RCTs) found that MSM may provide some relief from OA symptoms, such as pain and physical function, but more research is needed to confirm these findings (3).

A 2020 study published in the Journal of Functional Foods found that MSM may reduce inflammation and oxidative stress in overweight and obese adults (4). Another study published in the Journal of Clinical Biochemistry and Nutrition found that MSM may help reduce exercise-induced muscle damage and inflammation in healthy men (5).

While these studies suggest that MSM may have potential benefits for OA and inflammation, more research is needed to determine its safety and effectiveness. It is also important to note that MSM is not a cure for these conditions and should not be used as a replacement for medical treatment.

Safety and Dosage

MSM is generally considered safe for most people when taken in appropriate doses. The recommended dosage for MSM supplements varies depending on the product and condition being treated. It is important to follow the instructions on the label or consult with a healthcare provider before taking MSM.

While MSM is generally safe, some people may experience side effects, such as nausea, diarrhea, and headache. It is also possible that MSM may interact with certain medications, such as blood thinners, so it is important to talk to a healthcare provider before taking MSM.

Conclusion

In conclusion, MSM is a natural supplement that may provide some relief from OA and inflammation. While more research is needed, preliminary studies suggest that MSM may reduce inflammation, promote collagen formation, and alleviate OA symptoms. It is important to note that MSM is not a cure for these conditions and should not be used as a replacement for medical treatment. Before taking MSM or any other supplement, it is important to talk to a healthcare provider to determine if it is safe and appropriate for you.